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Nizoral, a broad-spectrum antifungal drug available in tablet form,
may be given to treat several fungal infections within the body, including
oral thrush and candidiasis.
It may also be given to treat severe, hard-to-treat fungal skin infections
that have not cleared up after treatment with creams or ointments,
or the oral drug griseofulvin (Fulvicin, Grisactin). Most important fact about Nizoral
In some people, Nizoral may cause serious or even fatal damage to
the liver. Before starting to take Nizoral, and at frequent intervals
while you are taking it, you should have blood tests to evaluate your
liver function. Tell your doctor immediately if you experience any
signs or symptoms that could mean liver damage: these include unusual
fatigue, loss of appetite, nausea or vomiting, jaundice, dark urine,
or pale stools. How should you take Nizoral without prescriptions?
Take Nizoral exactly as prescribed.
You should keep taking the drug until tests show that your fungal
infection has subsided. If you stop too soon, the infection might return.
You may want to take Nizoral Tablets with meals to avoid stomach upset.
Avoid alcohol and do not take with antacids. If antacids are necessary,
you should wait 2 to 3 hours before taking them.
If you miss a dose -
Take the forgotten dose as soon as you remember. This will help to
keep the proper amount of medicine in the body. However, if it is almost
time for your next dose, skip the one you missed and go back to your
regular schedule. Do not take double doses.
Storage instructions --
Nizoral should be stored at room temperature. Nizoral (Ketoconazole) side effects
Side effects from Nizoral cannot be anticipated. If any develop or
change in intensity, inform your doctor as soon as possible. Only your
doctor can determine if it is safe for you to continue taking Nizoral.
* Side effects may include:
Nausea, vomiting
Why should Nizoral not be prescribed?
Do not take Nizoral if you are sensitive to it or have ever had an
allergic reaction to it. Never take Nizoral together with Seldane,
Hismanal, Halcion, or Propulsid. Rare, but sometimes fatal reactions
have been reported when these drugs are combined.
Special warnings about Nizoral
In rare cases, people have had anaphylaxis (a life-threatening allergic
reaction) after taking their first dose of Nizoral.
Observe caution when driving or performing other tasks requiring alertness,
due to potential side effects of headache, dizziness, and drowsiness.
Possible food and drug interactions when taking Nizoral
If Nizoral is taken with certain other drugs, the effects of either
could be increased, decreased, or altered. It is especially important
to check with your doctor before combining Nizoral with the following:
Alcoholic beverages
Antacids such as Di-Gel, Maalox, Mylanta, and others
Anticoagulants such as Coumadin, Dicumarol, and others
Anti-ulcer medications such as Axid, Pepcid, Tagamet, and Zantac
Astemizole (Hismanal)
Cisapride (Propulsid)
Cyclosporine (Sandimmune, Neoral)
Digoxin (Lanoxin)
Drugs that relieve spasms, such as Donnatal
Isoniazid (Nydrazid)
Methylprednisolone (Medrol)
Midazolam (Versed)
Oral diabetes drugs such as Diabinese and Micronase
Phenytoin (Dilantin)
Rifampin (Rifadin, Rifamate, and Rimactane)
Tacrolimus (Prograf)
Terfenadine (Seldane)
Theophyllines (Slo-Phyllin, Theo-Dur, others)
Triazolam (Halcion)
Special information if you are pregnant or breastfeeding
If you are pregnant or plan to become pregnant, inform your doctor
immediately. Nizoral should be taken during pregnancy only if the benefit
outweighs the possible harm to your unborn child.
Since Nizoral can probably make its way into breast milk, it should
not be taken during breastfeeding. If you are a new mother, check with
your doctor. You may need to stop breastfeeding while you are taking
Nizoral. Recommended dosage for Nizoral
ADULTS
Overdosage
Although no specific information is available, any medication taken
in excess can have serious consequences. If you suspect an overdose
of Nizoral, seek medical attention immediately.
What is the most important information I should know about Nizoral?
Do not take Nizoral if you are taking astemizole (Hismanal), cisapride (Propulsid), triazolam (Halcion), or midazolam (Versed). Combined with these drugs, Nizoral could cause serious, even fatal, side effects.
In rare cases, Nizoral has caused severe liver damage, sometimes resulting in death. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, dark urine, or clay colored stools. These symptoms may be early signs of liver damage.
Take all of the Nizoral that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
What is Nizoral?
Nizoral is an antifungal medication. It is like an antibiotic but is used to treat fungal infections.
Nizoral is used to treat yeast infections of the mouth, throat, and esophagus; fungal infections throughout the whole body; and serious fungal infections of the skin and nails.
Nizoral may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking Nizoral?
Do not take Nizoral if you are taking any of the following drugs:
astemizole (Hismanal),
cisapride (Propulsid), or
triazolam (Halcion) or midazolam (Versed).
Dangerous or life-threatening events may occur if Nizoral is taken with any of the medicines listed above.
Before taking Nizoral, tell your doctor if you have
liver disease; or
achlorhydria (decreased stomach acid production) or if you take antacids, stomach acid reducers, or stomach ulcer medicines.
You may not be able to take Nizoral, or you may require a dosage adjustment, special monitoring, or special directions for use during your treatment.
Nizoral is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Nizoral passes into breast milk and may be harmful to a nursing baby. For this reason, Nizoral should not be taken by nursing mothers. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
How should I take Nizoral?
Take Nizoral exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Nizoral is usually taken once a day. Follow your doctor's instructions.
If you have a condition that decreases the amount of acid produced by the stomach, you may require a special mixture of this medication. Drink this solution through a straw far back in the mouth away from the teeth and follow each dose with a swish and swallow of water to prevent damage to the teeth.
It is important to take Nizoral regularly to get the most benefit.
Your doctor may want you to have blood tests or other medical evaluations during treatment with Nizoral to monitor progress and side effects.
Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.
What happens if I overdose?
Seek emergency medical attention if an overdose is suspected.
Symptoms of a Nizoral overdose are not well known but might include dizziness, ringing in the ears, headache, nausea, vomiting, diarrhea, and abdominal pain.
What should I avoid while taking Nizoral?
Alcohol should be used with moderation while taking Nizoral. Alcohol and Nizoral can both affect the liver. Rarely, flushing, nausea, vomiting, headache, swelling, and rashes have occurred when alcohol has been used during Nizoral therapy.
Use caution when driving or performing other hazardous activities. Nizoral may cause dizziness. If you experience dizziness, avoid these activities.
What are the possible side effects of Nizoral?
If you experience any of the following serious side effects, stop taking Nizoral and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
liver damage (pale stools, yellowish skin or eyes, abdominal pain, unusual fatigue, or dark urine).
Other, less serious side effects may be more likely to occur. If you experience any of the following side effects, continue to take Nizoral and talk to your doctor:
nausea, vomiting, or abdominal pain;
diarrhea;
headache;
dizziness;
fatigue; or
itching.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect Nizoral?
Do not take Nizoral if you are taking any of the following drugs:
astemizole (Hismanal),
cisapride (Propulsid), or
triazolam (Halcion) or midazolam (Versed).
Dangerous or life-threatening events may occur if Nizoral is taken with any of the medicines listed above.
Before taking Nizoral, tell your doctor if you are taking any other medicines, especially any of the following:
omeprazole (Prilosec), lansoprazole (Prevacid), or rabeprazole (Aciphex);
digoxin (Lanoxin, Lanoxicaps);
warfarin (Coumadin);
phenytoin (Dilantin, others);
rifampin (Rifadin, Rimactane); or
an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others.
You may not be able to take Nizoral, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with Nizoral or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
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